dcsimg

Distribution in Egypt

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Nile region, eastern desert, and Sinai.

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Global Distribution

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Tropical and subtropical regions.

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Habitat

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Moist ground, ditches.

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Life Expectancy

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Perennial.

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Comments

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For a discussion on the nomenclature of the species, see Philcox (Kew Bull. 33: 679-680. 1979).
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Missouri Botanical Garden, 4344 Shaw Boulevard, St. Louis, MO, 63110 USA
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Flora of China Vol. 18: 21 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Flora of China @ eFloras.org
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Wu Zhengyi, Peter H. Raven & Hong Deyuan
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Description

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Stems creeping, rooting at nodes, succulent, glabrous. Leaves sessile, oblong-oblanceolate, 0.8-2 cm X 3-6 mm, margin entire or rarely dentate, apex rounded. Flowers axillary. Pedicel 0.5-3.5 cm. Bracteoles 2, linear, below calyx. Sepals 5, ca. 5 mm; lower and upper sepals ovate-lanceolate; lateral 2 sepals lanceolate to linear. Corolla blue, purple, or white, 8-10 mm, obscurely 2-lipped. Stamens didynamous. Stigma capitate. Capsule narrowly ovoid, enveloped in persistent calyx, apex acute. Seeds yellow-brown, ellipsoid, truncate at one end, longitudinally striate. Fl. May-Oct.
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Missouri Botanical Garden, 4344 Shaw Boulevard, St. Louis, MO, 63110 USA
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Flora of China Vol. 18: 21 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Flora of China @ eFloras.org
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Wu Zhengyi, Peter H. Raven & Hong Deyuan
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Distribution

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Subtropical Himalaya, India, Ceylon, east to W. & S. China, Taiwan.
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Missouri Botanical Garden, 4344 Shaw Boulevard, St. Louis, MO, 63110 USA
bibliographic citation
Annotated Checklist of the Flowering Plants of Nepal Vol. 0 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Annotated Checklist of the Flowering Plants of Nepal @ eFloras.org
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K.K. Shrestha, J.R. Press and D.A. Sutton
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Distribution

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Fujian, Guangdong, Guangxi, Hainan, Taiwan, Yunnan [widespread in tropics and subtropics].
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Missouri Botanical Garden, 4344 Shaw Boulevard, St. Louis, MO, 63110 USA
bibliographic citation
Flora of China Vol. 18: 21 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Flora of China @ eFloras.org
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Wu Zhengyi, Peter H. Raven & Hong Deyuan
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Elevation Range

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700-900 m
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Missouri Botanical Garden, 4344 Shaw Boulevard, St. Louis, MO, 63110 USA
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Annotated Checklist of the Flowering Plants of Nepal Vol. 0 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Annotated Checklist of the Flowering Plants of Nepal @ eFloras.org
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K.K. Shrestha, J.R. Press and D.A. Sutton
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Habitat

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By water, wet places, sandy beaches; below 1100 m.
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Missouri Botanical Garden, 4344 Shaw Boulevard, St. Louis, MO, 63110 USA
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Flora of China Vol. 18: 21 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
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Flora of China @ eFloras.org
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Wu Zhengyi, Peter H. Raven & Hong Deyuan
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Synonym

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Lysimachia monnieri Linnaeus, Cent. Pl. II 9. 1756; Bacopa monnieria (Linnaeus) Wettstein; Gratiola monnieri (Linnaeus) Linnaeus.
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Missouri Botanical Garden, 4344 Shaw Boulevard, St. Louis, MO, 63110 USA
bibliographic citation
Flora of China Vol. 18: 21 in eFloras.org, Missouri Botanical Garden. Accessed Nov 12, 2008.
source
Flora of China @ eFloras.org
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Wu Zhengyi, Peter H. Raven & Hong Deyuan
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eFloras.org
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Bacopa monnieri

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Bacopa monnieri is a perennial, creeping herb native to the wetlands of southern and Eastern India, Australia, Europe, Africa, Asia, and North and South America.[2] It is known by the common names water hyssop,[1] waterhyssop, brahmi,[2] thyme-leafed gratiola, herb of grace,[2] and Indian pennywort.[2] Bacopa monnieri is used in Ayurveda. In 2019, the US Food and Drug Administration (FDA) warned manufacturers of dietary supplement products containing Bacopa monnieri against making illegal and unproven claims that the herb can treat various diseases.[3][4][5]

Description

Bacopa monnieri in Hyderabad, India

Bacopa monnieri is a non-aromatic herb. The leaves of this plant are succulent, oblong, and 4–6 mm (0.16–0.24 in) thick. Leaves are oblanceolate and are arranged oppositely on the stem. The flowers are small, actinomorphic and white, with four to five petals. It can even grow in slightly brackish conditions. Propagation is often achieved through cuttings.[6]

Ecology

Bacopa monnieri is one of the most widespread Bacopa species. It commonly grows in marshy areas throughout India, Nepal, Sri Lanka, China, Pakistan, Taiwan, Vietnam, tropical and southern Africa, on Madagascar, in Australia, in the Caribbean as well as in Middle and South America.[2] It is also found in Florida, Louisiana, Texas, and Hawaii.[1][7]

It used to be found growing wild in freshwater swamps of Singapore and nearby regions known as beremi.[8]

Research and regulation

Bacopa monnieri is used in Ayurvedic traditional medicine to improve memory and to treat various ailments.[9] Systematic reviews of preliminary research found that Bacopa monnieri may improve cognition, specifically memory and learning,[9][10] although the effect was measurable only after several weeks of use.[11]

In 2019, the FDA issued warning letters to manufacturers of dietary supplements containing Bacopa monnieri that advertised health claims for treating or preventing stomach disease, Alzheimer's disease, hypoglycemia, blood pressure, and anxiety were unproven and illegal. The FDA stated that Bacopa monnieri products have not been approved for these or any medical purposes.[3][4][5]

Adverse effects

The most commonly reported adverse effects of Bacopa monnieri in humans are nausea, increased intestinal motility, and gastrointestinal upset.[9]

Phytochemistry

The best characterized phytochemicals in Bacopa monnieri are dammarane-type triterpenoid saponins known as bacosides, with jujubogenin or pseudo-jujubogenin moieties as aglycone units.[12] Bacosides comprise a family of 12 known analogs.[13] Other saponins called bacopasides I–XII were identified.[14] The alkaloids brahmine, nicotine, and herpestine have been catalogued, along with D-mannitol, apigenin, hersaponin, monnierasides I–III, cucurbitacin and plantainoside B.[15][16][17]

References

  1. ^ a b c Lansdown, R.V.; Knees, S.G.; Patzelt, A. (2013). "Bacopa monnieri". IUCN Red List of Threatened Species. 2013: e.T164168A17722668. doi:10.2305/IUCN.UK.2013-1.RLTS.T164168A17722668.en. Retrieved 19 November 2021.
  2. ^ a b c d e f "Bacopa monnieri". Germplasm Resources Information Network (GRIN). Agricultural Research Service (ARS), United States Department of Agriculture (USDA). Retrieved 2008-03-13.
  3. ^ a b "Health fraud scams: Unproven Alzheimer's disease products (Bacopa monnieri listed)". US Food and Drug Administration. 22 December 2018. Retrieved 11 May 2019.
  4. ^ a b William A Correll, Jr. (5 February 2019). "FDA Warning Letter: Peak Nootropics LLC aka Advanced Nootropics". Office of Compliance, Center for Food Safety and Applied Nutrition, Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Retrieved 11 May 2019.
  5. ^ a b William A Correll, Jr. (5 February 2019). "FDA Warning Letter: TEK Naturals". Office of Compliance, Center for Food Safety and Applied Nutrition, Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Retrieved 11 May 2019.
  6. ^ Oudhia, Pankaj (2004). "Bramhi (Bacopa monnieri)". Society for Parthenium Management (SOPAM). Retrieved July 30, 2017.
  7. ^ "Plants of Louisiana". warcapps.usgs.gov. Retrieved 2021-07-23.
  8. ^ Khir Johari (Oct–Dec 2021). "The Role of Foraging in Malay Cuisine". BiblioAsia. Vol. 17, no. 3. National Library Board, Singapore. pp. 20–23.{{cite magazine}}: CS1 maint: date format (link)
  9. ^ a b c Aguiar, Sebastian; Borowski, Thomas (2013). "Neuropharmacological review of the nootropic herb Bacopa monnieri". Rejuvenation Research. 16 (4): 313–326. doi:10.1089/rej.2013.1431. ISSN 1557-8577. PMC 3746283. PMID 23772955.
  10. ^ Kongkeaw, C; Dilokthornsakul, P; Thanarangsarit, P; Limpeanchob, N; Norman Scholfield, C (2014). "Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract". Journal of Ethnopharmacology. 151 (1): 528–35. doi:10.1016/j.jep.2013.11.008. PMID 24252493.
  11. ^ Neale, Chris; Camfield, David; Reay, Jonathon; Stough, Con; Scholey, Andrew (5 February 2013). "Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes". British Journal of Clinical Pharmacology. 75 (3): 728–737. doi:10.1111/bcp.12002. ISSN 0306-5251. PMC 3575939. PMID 23043278.
  12. ^ Sivaramakrishna, C; Rao, CV; Trimurtulu, G; Vanisree, M; Subbaraju, GV (2005). "Triterpenoid glycosides from Bacopa monnieri". Phytochemistry. 66 (23): 2719–2728. Bibcode:2005PChem..66.2719S. doi:10.1016/j.phytochem.2005.09.016. PMID 16293276.
  13. ^ Garai, S; Mahato, SB; Ohtani, K; Yamasaki, K (2009). "Dammarane triterpenoid saponins from Bacopa monnieri". Can J Chem. 87 (9): 1230–1234. doi:10.1139/V09-111.
  14. ^ Chakravarty, A.K; Garai, S.; Masuda, K; Nakane, T; Kawahara, N. (2003). "Bacopasides III–V: Three new triterpenoid glycosides from Bacopa monnieri". Chem Pharm Bull. 51 (2): 215–217. doi:10.1248/cpb.51.215. PMID 12576661.
  15. ^ Chatterji, N; Rastogi, RP; Dhar, ML (1965). "Chemical examination of Bacopa monniera Wettst: Part II—Isolation of chemical constituents". Ind J Chem. 3: 24–29.
  16. ^ Chakravarty, AK; Sarkar, T; Nakane, T; Kawahara, N; Masuda, K (2008). "New phenylethanoid glycosides from Bacopa monnieri". Chem Pharm Bull. 50 (12): 1616–1618. doi:10.1248/cpb.50.1616. PMID 12499603.
  17. ^ Bhandari, Pamita; Kumar, Neeraj; Singh, Bikram; Kaul, Vijay K. (2007). "Cucurbitacins from Bacopa monnieri". Phytochemistry. 68 (9): 1248–1254. Bibcode:2007PChem..68.1248B. doi:10.1016/j.phytochem.2007.03.013. ISSN 0031-9422. PMID 17442350.

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Bacopa monnieri: Brief Summary

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Bacopa monnieri is a perennial, creeping herb native to the wetlands of southern and Eastern India, Australia, Europe, Africa, Asia, and North and South America. It is known by the common names water hyssop, waterhyssop, brahmi, thyme-leafed gratiola, herb of grace, and Indian pennywort. Bacopa monnieri is used in Ayurveda. In 2019, the US Food and Drug Administration (FDA) warned manufacturers of dietary supplement products containing Bacopa monnieri against making illegal and unproven claims that the herb can treat various diseases.

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