Acmispon americanus americanus

are host of

• Global Biotic Interactions: Plebejus acmon (Westwood (1852))
• Global Biotic Interactions: Uromyces striatus J. Schröt. 1870
• Global Biotic Interactions: Pleospora herbarum
• Global Biotic Interactions: Ovularia lotophaga
• Global Biotic Interactions: Erysiphe polygoni DC. 1821

are mutualistic with

• Global Biotic Interactions: Ashmeadiella cactorum basalis
• Global Biotic Interactions: Osmia regulina Cockerell 1911

have flowers visited by

• Global Biotic Interactions: Ashmeadiella cactorum basalis
• Global Biotic Interactions: Megachile angelarum Cockerell 1902
• Global Biotic Interactions: Megachile brevis Say 1837 (Common Little Leaf-cutter Bee)