Delphinium nudicaule hybridizes with most other taxa of Delphinium that it encounters. Apparent hybrids involving D . nudicaule , and seen by the author (either afield or as specimens), include D . andersonii , D . antoninum , D . decorum , D . luteum , D . nuttallianum , D . patens , and D . trolliifolium . In addition, garden-grown plants have been hybridized with D . cardinale , D . elatum , D . menziesii , D . parishii , D . penardii , D . tatsienense Franchet, D . triste Fischer ex de Candolle, and D . uliginosum ; D . nudicaule does not naturally occur with these species. Delphinium nudicaule is one of the earliest larkspurs to flower in any given locality. Douglas's type collection of D . nudicaule represents plants (synonyms D . sarcophyllum Hooker & Arnott and D . peltatum Hooker, an invalid name) grown under very moist conditions, probably quite near the ocean. The type specimen of D . armeniacum A. Heller represents plants grown under unusually dry conditions.
The Mendocino Indians consider Delphinium nudicaule a narcotic (D. E. Moerman 1986).