It grows on slopes and gulches in a small stretch of shrubland on the southern side of East Mauʻi island. There is one population located in Kamole Gulch, the type locality. In 2005 this population contained only 25 mature plants.
Melanthera kamolensis is a sprawling perennial herb.
Melanthera kamolensis is federally listed as an endangered species of the United States.
Melanthera kamolensis (formerly Lipochaeta kamolensis), known by the common name Maui nehe, is a rare species of flowering plant in the aster family.